Mass spectrometry in the diagnosis of steroid-related disorders and in hypertension research
CHL Shackleton - The Journal of steroid biochemistry and molecular …, 1993 - Elsevier
CHL Shackleton
The Journal of steroid biochemistry and molecular biology, 1993•ElsevierThe use of GC/MS and microbore HPLC/electrospray mass spectrometry for clinical studies
in hypertension and mineralocorticoid research is described. In particular, an automated
GC/MS method allows nearly quantitative measurements of metabolites of major steroids of
adrenal, placental and gonadal origin. This method is able to distinguish almost all steroid
related disorders. Electrospray mass spectrometry in conjunction with microbore HPLC is
the latest mass spectrometry technique applicable to biochemical investigations. It offers …
in hypertension and mineralocorticoid research is described. In particular, an automated
GC/MS method allows nearly quantitative measurements of metabolites of major steroids of
adrenal, placental and gonadal origin. This method is able to distinguish almost all steroid
related disorders. Electrospray mass spectrometry in conjunction with microbore HPLC is
the latest mass spectrometry technique applicable to biochemical investigations. It offers …
The use of GC/MS and microbore HPLC/electrospray mass spectrometry for clinical studies in hypertension and mineralocorticoid research is described. In particular, an automated GC/MS method allows nearly quantitative measurements of metabolites of major steroids of adrenal, placental and gonadal origin. This method is able to distinguish almost all steroid related disorders. Electrospray mass spectrometry in conjunction with microbore HPLC is the latest mass spectrometry technique applicable to biochemical investigations. It offers high sensitivity (15 pg) for measurement of intact steroid conjugates and related compounds.
Elsevier