Renal interstitial fluid angiotensin I and angiotensin II concentrations during local angiotensin-converting enzyme inhibition
A Nishiyama, DM Seth, LG Navar - Journal of the American …, 2002 - journals.lww.com
It was recently demonstrated that angiotensin II (AngII) concentrations in the renal interstitial
fluid (RIF) of anesthetized rats were in the nanomolar range and were not reduced by intra-
arterial infusion of an angiotensin-converting enzyme (ACE) inhibitor (enalaprilat). This
study was performed to determine changes in RIF AngI and AngII concentrations during
interstitial administration of ACE inhibitors (enalaprilat and perindoprilat). Studies were also
performed to determine the effects of enalaprilat on the de novo formation of RIF AngII …
fluid (RIF) of anesthetized rats were in the nanomolar range and were not reduced by intra-
arterial infusion of an angiotensin-converting enzyme (ACE) inhibitor (enalaprilat). This
study was performed to determine changes in RIF AngI and AngII concentrations during
interstitial administration of ACE inhibitors (enalaprilat and perindoprilat). Studies were also
performed to determine the effects of enalaprilat on the de novo formation of RIF AngII …