Production of actinonin, an inhibitor of aminopeptidase M, by actinomycetes
H UMEZAWA, T AOYAGI, T TANAKA… - The Journal of …, 1985 - jstage.jst.go.jp
H UMEZAWA, T AOYAGI, T TANAKA, H SUDA, A OKUYAMA, H NAGANAWA, M HAMADA…
The Journal of antibiotics, 1985•jstage.jst.go.jpAs we have previously reported, inhibitors of various endopeptidases and exopeptidases
have been found in culture filtrates of microorganisms'-'), and all of them were new
compounds as shown by determination of their structures. But as reported in this paper,
searching for inhibitors of aminopeptidase M (EC 3.4. 11.2), we isolated the known
actinoniną'and found that this antibiotic inhibits aminopeptidases. We report the screening
method and isolation and identification of actinonin because of the importance of its …
have been found in culture filtrates of microorganisms'-'), and all of them were new
compounds as shown by determination of their structures. But as reported in this paper,
searching for inhibitors of aminopeptidase M (EC 3.4. 11.2), we isolated the known
actinoniną'and found that this antibiotic inhibits aminopeptidases. We report the screening
method and isolation and identification of actinonin because of the importance of its …
As we have previously reported, inhibitors of various endopeptidases and exopeptidases have been found in culture filtrates of microorganisms'-'), and all of them were new compounds as shown by determination of their structures. But as reported in this paper, searching for inhibitors of aminopeptidase M (EC 3.4. 11.2), we isolated the known actinoniną'and found that this antibiotic inhibits aminopeptidases. We report the screening method and isolation and identification of actinonin because of the importance of its inhibitory activities.
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