Visceral surface oxygen tension in experimental colitis in the rabbit
CJ Hauser, RR Locke, HW Kao… - The Journal of …, 1988 - translationalres.com
The impairment of bowel healing that is characteristic of inflammatory bowel disease (IBD) is
poorly understood. Because bowel healing is related to the adequacy of perfusion in other
circumstances, we studied bowel surface oxygen tension (Pso 2), which is related to bowel
perfusion, in rabbits with IBD. Both cell-mediated (n= 17) and immune complex-mediated
(n= 10) colitis caused marked attenuation of colon Pso 2. Control (n= 13) left colon Pso 2
was 36±5 (SEM) torr. In mild colitis, left colon Pso 2 fell to 11±5 torr, and in severe colitis it …
poorly understood. Because bowel healing is related to the adequacy of perfusion in other
circumstances, we studied bowel surface oxygen tension (Pso 2), which is related to bowel
perfusion, in rabbits with IBD. Both cell-mediated (n= 17) and immune complex-mediated
(n= 10) colitis caused marked attenuation of colon Pso 2. Control (n= 13) left colon Pso 2
was 36±5 (SEM) torr. In mild colitis, left colon Pso 2 fell to 11±5 torr, and in severe colitis it …