[HTML][HTML] Extracellular export of sphingosine kinase-1 enzyme: sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation

N Ancellin, C Colmont, J Su, Q Li, N Mittereder… - Journal of Biological …, 2002 - ASBMB
The enzyme sphingosine kinase (SK) catalyzes the formation of sphingosine 1-phosphate
(S1P), a bioactive lipid that acts extracellularly on G protein-coupled receptors of the S1P
1/EDG-1 subfamily. Although S1P is formed in the cytosol of various cells, S1P release is not
understood and is controversial because this lipid mediator is also regarded as a second
messenger. In this report, we describe the existence of an extracellular S1P-generating
system in vascular endothelial cells. Endothelial cells release SK constitutively and form …