[HTML][HTML] The enzymatic and DNA binding activity of PARP-1 are not required for NF-κB coactivator function
PO Hassa, M Covic, S Hasan, R Imhof… - Journal of Biological …, 2001 - ASBMB
Poly (ADP-ribose) polymerase 1 (PARP-1)-deficient mice are protected against septic shock,
diabetes type I, stroke, and inflammation. We report that primary cells from PARP-1−/−
animals are impaired in κB-dependent transcriptional activation induced by different stimuli
involved in inflammatory and genotoxic stress signaling. PARP-1 was also required for p65-
mediated transcriptional activation. PARP-1 enzymatic inhibitors did not inhibit the
transcriptional activation of a κB-dependent reporter gene in wild type cells. Remarkably …
diabetes type I, stroke, and inflammation. We report that primary cells from PARP-1−/−
animals are impaired in κB-dependent transcriptional activation induced by different stimuli
involved in inflammatory and genotoxic stress signaling. PARP-1 was also required for p65-
mediated transcriptional activation. PARP-1 enzymatic inhibitors did not inhibit the
transcriptional activation of a κB-dependent reporter gene in wild type cells. Remarkably …