[PDF][PDF] The nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure and normal values
SS Kety, CF Schmidt - The Journal of clinical investigation, 1948 - Am Soc Clin Investig
SS Kety, CF Schmidt
The Journal of clinical investigation, 1948•Am Soc Clin InvestigDISCUSSION Before this technique can be regarded as capable of yielding valid
measurements of cerebral blood flow the assumptions on which it is based must be
subjected to experimental verification. This was recognized in our original description of the
method (1) and evidence was adduced to validate the assumptions. Since that time it has
beenpossible to make a more exhaustive evaluation of these assumptions and to determine
more precisely the value of the constant S. Blood from one internal jugular bulb as …
measurements of cerebral blood flow the assumptions on which it is based must be
subjected to experimental verification. This was recognized in our original description of the
method (1) and evidence was adduced to validate the assumptions. Since that time it has
beenpossible to make a more exhaustive evaluation of these assumptions and to determine
more precisely the value of the constant S. Blood from one internal jugular bulb as …
DISCUSSION
Before this technique can be regarded as capable of yielding valid measurements of cerebral blood flow the assumptions on which it is based must be subjected to experimental verification. This was recognized in our original description of the method (1) and evidence was adduced to validate the assumptions. Since that time it has beenpossible to make a more exhaustive evaluation of these assumptions and to determine more precisely the value of the constant S.
Blood from one internal jugular bulb as representative of mixed cerebral venous blood The method yields values for mean cerebral blood flow only insofar as the venous blood sam-ples obtained from one internal jugular are repre-sentative of mixed cerebral venous blood. Three studies of oxygen content in samples taken simultaneously or in rapid succession from both right
The Journal of Clinical Investigation