Selectins: lectins that initiate cell adhesion under flow
RP McEver - Current opinion in cell biology, 2002 - Elsevier
RP McEver
Current opinion in cell biology, 2002•ElsevierInteractions of selectins with cell-surface glycoconjugates mediate tethering and rolling
adhesion of leukocytes and platelets on vascular surfaces. Recent studies have helped
elucidate the molecular details of selectin–ligand interactions, the biosynthetic pathways for
constructing selectin ligands, and the biophysical and cell biological features that modulate
selectin-dependent rolling under flow.
adhesion of leukocytes and platelets on vascular surfaces. Recent studies have helped
elucidate the molecular details of selectin–ligand interactions, the biosynthetic pathways for
constructing selectin ligands, and the biophysical and cell biological features that modulate
selectin-dependent rolling under flow.
Interactions of selectins with cell-surface glycoconjugates mediate tethering and rolling adhesion of leukocytes and platelets on vascular surfaces. Recent studies have helped elucidate the molecular details of selectin–ligand interactions, the biosynthetic pathways for constructing selectin ligands, and the biophysical and cell biological features that modulate selectin-dependent rolling under flow.
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