Antiproliferative action of cyclic GMP-elevating vasodilators in cultured rabbit aortic smooth muscle cells
K Kariya, Y Kawahara, S Araki, H Fukuzaki, Y Takai - Atherosclerosis, 1989 - Elsevier
In cultured rabbit aortic smooth muscle cells (SMCs), sodium nitroprusside (SNP)(10− 7 to
10− 4 M), atrial natriuretic peptide (ANP)(10− 9 to 10− 6 M) and 8-bromo-cyclic GMP (10− 6
to 10− 3 M) inhibited the whole blood serum (WBS)-induced DNA synthesis by about 30%.
The doses of SNP and ANP necessary for the inhibition of the WBS-induced DNA synthesis
were similar to those necessary for the formation of cellular cyclic GMP (cGMP). These
agents were effective even when added 6 h after stimulation of the cells with WBS. These …
10− 4 M), atrial natriuretic peptide (ANP)(10− 9 to 10− 6 M) and 8-bromo-cyclic GMP (10− 6
to 10− 3 M) inhibited the whole blood serum (WBS)-induced DNA synthesis by about 30%.
The doses of SNP and ANP necessary for the inhibition of the WBS-induced DNA synthesis
were similar to those necessary for the formation of cellular cyclic GMP (cGMP). These
agents were effective even when added 6 h after stimulation of the cells with WBS. These …