[HTML][HTML] Insulin stimulates pp120 endocytosis in cells co-expressing insulin receptors
pp120, a substrate of the insulin receptor tyrosine kinase, is a plasma membrane
glycoprotein that is expressed in the hepatocyte as two spliced isoforms differing by the
presence (full-length) or absence (truncated) of most of the intracellular domain including all
phosphorylation sites. Co-expression of full-length pp120, but not its phosphorylation-
defective isoforms, increased receptor-mediated insulin endocytosis and degradation in NIH
3T3 fibroblasts. We, herein, examined whether internalization of pp120 is required to …
glycoprotein that is expressed in the hepatocyte as two spliced isoforms differing by the
presence (full-length) or absence (truncated) of most of the intracellular domain including all
phosphorylation sites. Co-expression of full-length pp120, but not its phosphorylation-
defective isoforms, increased receptor-mediated insulin endocytosis and degradation in NIH
3T3 fibroblasts. We, herein, examined whether internalization of pp120 is required to …