[HTML][HTML] Insulin-like growth factor I (IGF-I)-stimulated pancreatic β-cell growth is glucose-dependent: synergistic activation of insulin receptor substrate-mediated signal …
SR Hugl, MF White, CJ Rhodes - Journal of Biological Chemistry, 1998 - ASBMB
Nutrients and certain growth factors stimulate pancreatic β-cell mitogenesis, however, the
appropriate mitogenic signal transduction pathways have not been defined. In the glucose-
sensitive pancreatic β-cell line, INS-1, it was found that glucose (6–18 mm) independently
increased INS-1 cell proliferation (> 20-fold at 15 mm glucose). Insulin-like growth factor I
(IGF-I)-induced INS-1 cell proliferation was glucose-dependent only in the physiologically
relevant concentration range (6–18 mm glucose). The combination of IGF-I and glucose was …
appropriate mitogenic signal transduction pathways have not been defined. In the glucose-
sensitive pancreatic β-cell line, INS-1, it was found that glucose (6–18 mm) independently
increased INS-1 cell proliferation (> 20-fold at 15 mm glucose). Insulin-like growth factor I
(IGF-I)-induced INS-1 cell proliferation was glucose-dependent only in the physiologically
relevant concentration range (6–18 mm glucose). The combination of IGF-I and glucose was …