Interferons as antiangiogenic agents
DJ Lindner - Current Oncology Reports, 2002 - Springer
Current Oncology Reports, 2002•Springer
Interferons (IFNs), pleiotropic cytokines that regulate antiviral, antitumor, apoptotic, and
cellular immune responses, were the first endogenous antiangiogenic regulators identified.
In a species-specific manner, IFNs inhibit secretion of such angiogenic factors as basic
fibroblast growth factor from tumor cells. The antiangiogenic activity of IFNs is enhanced
when they are combined with other antiangiogenic agents, such as tamoxifen and
thalidomide.
cellular immune responses, were the first endogenous antiangiogenic regulators identified.
In a species-specific manner, IFNs inhibit secretion of such angiogenic factors as basic
fibroblast growth factor from tumor cells. The antiangiogenic activity of IFNs is enhanced
when they are combined with other antiangiogenic agents, such as tamoxifen and
thalidomide.
Abstract
Interferons (IFNs), pleiotropic cytokines that regulate antiviral, antitumor, apoptotic, and cellular immune responses, were the first endogenous antiangiogenic regulators identified. In a species-specific manner, IFNs inhibit secretion of such angiogenic factors as basic fibroblast growth factor from tumor cells. The antiangiogenic activity of IFNs is enhanced when they are combined with other antiangiogenic agents, such as tamoxifen and thalidomide.
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