[HTML][HTML] Regulation of adrenal scavenger receptor-BI expression by ACTH and cellular cholesterol pools
Scavenger receptor BI (SR-BI) mediates selective uptake of high density lipoprotein (HDL)
cholesteryl ester in the liver and adrenal gland. Adrenal SR-BI is increased both in
adrenocorticotropic hormone (ACTH)-treated mice and also in apolipoprotein AI knock-out
(apoA-I0) mice which have depleted adrenal cholesterol stores. The goal of the present
study was to determine whether adrenal cholesterol stores and ACTH have independent
effects on SR-BI expression in adrenal gland. Adrenal SR-BI levels were 5-fold higher in …
cholesteryl ester in the liver and adrenal gland. Adrenal SR-BI is increased both in
adrenocorticotropic hormone (ACTH)-treated mice and also in apolipoprotein AI knock-out
(apoA-I0) mice which have depleted adrenal cholesterol stores. The goal of the present
study was to determine whether adrenal cholesterol stores and ACTH have independent
effects on SR-BI expression in adrenal gland. Adrenal SR-BI levels were 5-fold higher in …