Cellular control of renin secretion

A Kurtz, C Wagner - Journal of experimental biology, 1999 - journals.biologists.com
A Kurtz, C Wagner
Journal of experimental biology, 1999journals.biologists.com
Renin secretion at the level of renal juxtaglomerular cells appears to be controlled mainly by
classic second messengers such as Ca2+, cyclic AMP and cyclic GMP, which in turn exert
their effects through oppositely acting protein kinases and probably also by affecting the
activity of ion channels in the plasma membrane. Thus, protein kinase A stimulates renin
secretion, whilst protein kinase C and protein kinase G II inhibit renin secretion. Moreover,
Cl− channels could be involved in the mediation of the inhibitory action of Ca2+ on renin …
Abstract
Renin secretion at the level of renal juxtaglomerular cells appears to be controlled mainly by classic second messengers such as Ca2+, cyclic AMP and cyclic GMP, which in turn exert their effects through oppositely acting protein kinases and probably also by affecting the activity of ion channels in the plasma membrane. Thus, protein kinase A stimulates renin secretion, whilst protein kinase C and protein kinase G II inhibit renin secretion. Moreover, Cl channels could be involved in the mediation of the inhibitory action of Ca2+ on renin secretion. This review summarizes our present knowledge about the possible actions of these kinases in renal juxtaglomerular cells and considers pathways in the organ control of renin secretion.
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