Pathogenesis of the renal lesion associated with the abuse of analgesics
P Kincaid-Smith - The Lancet, 1967 - Elsevier
P Kincaid-Smith
The Lancet, 1967•ElsevierRenal papillary necrosis is the primary lesion in the kidney in patients who take large
quantities of analgesic drugs. Morbid-anatomical studies and biopsy and radiological data
show that the cortical changes of so-called chronic interstitial nephritis are the result of
atrophy which develops as a direct consequence of the papillary necrosis. It is suggested
that precipitation of excretion products of analgesic drugs due to the high urinary
concentration in the loops of Henle may initiate the pathological lesions which lead to …
quantities of analgesic drugs. Morbid-anatomical studies and biopsy and radiological data
show that the cortical changes of so-called chronic interstitial nephritis are the result of
atrophy which develops as a direct consequence of the papillary necrosis. It is suggested
that precipitation of excretion products of analgesic drugs due to the high urinary
concentration in the loops of Henle may initiate the pathological lesions which lead to …
Abstract
Renal papillary necrosis is the primary lesion in the kidney in patients who take large quantities of analgesic drugs. Morbid-anatomical studies and biopsy and radiological data show that the cortical changes of so-called chronic interstitial nephritis are the result of atrophy which develops as a direct consequence of the papillary necrosis. It is suggested that precipitation of excretion products of analgesic drugs due to the high urinary concentration in the loops of Henle may initiate the pathological lesions which lead to papillary necrosis.
Elsevier