Changes in cell cycle parameters and cell number in the rat midbrain during organogenesis
TA Lewandowski, RA Ponce, JS Charleston… - Developmental brain …, 2003 - Elsevier
We employed 5-bromo-2′-deoxyuridine (BrdU) labeling to identify in vivo changes in the
cell cycle patterns of the rat midbrain during the major period of midbrain organogenesis,
gestational days (gd) 11 to 16. We also used quantitative stereology to determine changes
in absolute cell numbers during these gestational time points. Between gd 12 and 16, the
length of S-phase did not change significantly while the fraction of cycling cells decreased
from 73 to 11%. The average cell cycle length was determined to be 15 h on gd 12 and 17 h …
cell cycle patterns of the rat midbrain during the major period of midbrain organogenesis,
gestational days (gd) 11 to 16. We also used quantitative stereology to determine changes
in absolute cell numbers during these gestational time points. Between gd 12 and 16, the
length of S-phase did not change significantly while the fraction of cycling cells decreased
from 73 to 11%. The average cell cycle length was determined to be 15 h on gd 12 and 17 h …