Novel mode of action of iloprost: in vitro down-regulation of endothelial cell adhesion molecules
S Della Bella, M Molteni, C Mocellin… - Prostaglandins & other …, 2001 - Elsevier
Iloprost is a stable prostacyclin analog commonly employed in the treatment of peripheral
vascular disease and also indicated in the treatment of patients affected by systemic
sclerosis (SSc) in the presence of severe Raynaud's phenomenon (RP). Several
mechanisms of action of the drug other than vasodilation and antiplatelet effect have been
demonstrated that may be involved in the exertion of its clinical efficacy. Aim of the present
study was to investigate whether iloprost down-regulated lymphocyte adhesion to …
vascular disease and also indicated in the treatment of patients affected by systemic
sclerosis (SSc) in the presence of severe Raynaud's phenomenon (RP). Several
mechanisms of action of the drug other than vasodilation and antiplatelet effect have been
demonstrated that may be involved in the exertion of its clinical efficacy. Aim of the present
study was to investigate whether iloprost down-regulated lymphocyte adhesion to …