Prostaglandins and renin release: II. Assessment of renin secretion following infusion of PGI2, E2 and D2 into the renal artery of anesthetized dogs
JG Gerber, RA Branch, AS Nies, JF Gerkens… - Prostaglandins, 1978 - Elsevier
The influence of intra-renal infusions of prostaglandin (PG) I 2, PGE 2 and PGD 2 on renin
secretion and renal blood flow was investigated in renally denervated, beta-adrenergic
blocked, indomethacin treated dogs with unilateral nephrectomy. All three prostaglandins
when infused at doses of 10− 8 g/kg/min and 10− 7 g/kg/min resulted in marked renal
vasodilation. Renin secretory rates increased significantly with both PGI 2 and PGE 2 at the
10− 8 g/kg/min and 10− 7 g/kg/min infusion rates in a dose dependent manner. However …
secretion and renal blood flow was investigated in renally denervated, beta-adrenergic
blocked, indomethacin treated dogs with unilateral nephrectomy. All three prostaglandins
when infused at doses of 10− 8 g/kg/min and 10− 7 g/kg/min resulted in marked renal
vasodilation. Renin secretory rates increased significantly with both PGI 2 and PGE 2 at the
10− 8 g/kg/min and 10− 7 g/kg/min infusion rates in a dose dependent manner. However …