Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled …
FE Silverstein, G Faich, JL Goldstein, LS Simon… - Jama, 2000 - jamanetwork.com
ContextConventional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with a
spectrum of toxic effects, notably gastrointestinal (GI) effects, because of inhibition of
cyclooxygenase (COX)-1. Whether COX-2–specific inhibitors are associated with fewer
clinical GI toxic effects is unknown. ObjectiveTo determine whether celecoxib, a COX-2–
specific inhibitor, is associated with a lower incidence of significant upper GI toxic effects and
other adverse effects compared with conventional NSAIDs. DesignThe Celecoxib Long-term …
spectrum of toxic effects, notably gastrointestinal (GI) effects, because of inhibition of
cyclooxygenase (COX)-1. Whether COX-2–specific inhibitors are associated with fewer
clinical GI toxic effects is unknown. ObjectiveTo determine whether celecoxib, a COX-2–
specific inhibitor, is associated with a lower incidence of significant upper GI toxic effects and
other adverse effects compared with conventional NSAIDs. DesignThe Celecoxib Long-term …