Transcription factors as targets for cancer therapy
JE Darnell Jr - Nature Reviews Cancer, 2002 - nature.com
JE Darnell Jr
Nature Reviews Cancer, 2002•nature.comA limited list of transcription factors are overactive in most human cancer cells, which makes
them targets for the development of anticancer drugs. That they are the most direct and
hopeful targets for treating cancer is proposed, and this is supported by the fact that there
are many more human oncogenes in signalling pathways than there are oncogenic
transcription factors. But how could specific transcription-factor activity be inhibited?
them targets for the development of anticancer drugs. That they are the most direct and
hopeful targets for treating cancer is proposed, and this is supported by the fact that there
are many more human oncogenes in signalling pathways than there are oncogenic
transcription factors. But how could specific transcription-factor activity be inhibited?
Abstract
A limited list of transcription factors are overactive in most human cancer cells, which makes them targets for the development of anticancer drugs. That they are the most direct and hopeful targets for treating cancer is proposed, and this is supported by the fact that there are many more human oncogenes in signalling pathways than there are oncogenic transcription factors. But how could specific transcription-factor activity be inhibited?
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