Immune response in mice that lack the interferon-γ receptor

S Huang, W Hendriks, A Althage, S Hemmi… - Science, 1993 - science.org
S Huang, W Hendriks, A Althage, S Hemmi, H Bluethmann, R Kamijo, J Vilček
Science, 1993science.org
Interferon-γ (IFN-γ) exerts pleiotropic effects, including antiviral activity, stimulation of
macrophages and natural killer cells, and increased expression of major histocompatibility
complex antigens. Mice without the IFN-γ receptor had no overt anomalies, and their
immune system appeared to develop normally. However, mutant mice had a defective
natural resistance; they had increased susceptibility to infection by Listeria monocytogenes
and vaccinia virus despite normal cytotoxic and T helper cell responses. Immunoglobulin …
Interferon-γ (IFN-γ) exerts pleiotropic effects, including antiviral activity, stimulation of macrophages and natural killer cells, and increased expression of major histocompatibility complex antigens. Mice without the IFN-γ receptor had no overt anomalies, and their immune system appeared to develop normally. However, mutant mice had a defective natural resistance; they had increased susceptibility to infection by Listeria monocytogenes and vaccinia virus despite normal cytotoxic and T helper cell responses. Immunoglobulin isotype analysis revealed that IFN-γ is necessary for a normal antigen-specific immunoglobulin G2a response. These mutant mice offer the possibility for the further elucidation of IFN-γ-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
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