Pathogenesis of systemic lupus erythematosus

CC Mok, CS Lau - Journal of clinical pathology, 2003 - jcp.bmj.com
Journal of clinical pathology, 2003jcp.bmj.com
The exact patho-aetiology of systemic lupus erythematosus (SLE) remains elusive. An
extremely complicated and multifactorial interaction among various genetic and
environmental factors is probably involved. Multiple genes contribute to disease
susceptibility. The interaction of sex, hormonal milieu, and the hypothalamo–pituitary–
adrenal axis modifies this susceptibility and the clinical expression of the disease. Defective
immune regulatory mechanisms, such as the clearance of apoptotic cells and immune …
The exact patho-aetiology of systemic lupus erythematosus (SLE) remains elusive. An extremely complicated and multifactorial interaction among various genetic and environmental factors is probably involved. Multiple genes contribute to disease susceptibility. The interaction of sex, hormonal milieu, and the hypothalamo–pituitary–adrenal axis modifies this susceptibility and the clinical expression of the disease. Defective immune regulatory mechanisms, such as the clearance of apoptotic cells and immune complexes, are important contributors to the development of SLE. The loss of immune tolerance, increased antigenic load, excess T cell help, defective B cell suppression, and the shifting of T helper 1 (Th1) to Th2 immune responses leads to B cell hyperactivity and the production of pathogenic autoantibodies. Finally, certain environmental factors are probably required to trigger the disease.
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