Adaptation to hyperoxia in the neonatal rat: kinetic parameters of the oxygen-mediated induction of lung superoxide dismutases, catalase and glutathione peroxidase
M Hoffman, JB Stevens - Toxicology, 1980 - Elsevier
The activities of the enzymes superoxide dismutase, catalase and glutathione peroxidase
increase in the lungs of neonatal rats exposed to normobaric hyperoxia. The oxygen-
mediated increase in activity of these enzymes, known from previous studies to be an
inductive response, was studied in 10-and 25-day-old rats as a function of both oxygen
concentration and length of time of exposure to greater than 95% oxygen. In the lungs of 10-
day-old rats the increase in superoxide dismutase, catalase, and glutathione peroxidase …
increase in the lungs of neonatal rats exposed to normobaric hyperoxia. The oxygen-
mediated increase in activity of these enzymes, known from previous studies to be an
inductive response, was studied in 10-and 25-day-old rats as a function of both oxygen
concentration and length of time of exposure to greater than 95% oxygen. In the lungs of 10-
day-old rats the increase in superoxide dismutase, catalase, and glutathione peroxidase …