Blockade of p38α MAPK ameliorates acute inflammatory renal injury in rat anti-GBM glomerulonephritis
C Stambe, RC Atkins, GH Tesch… - Journal of the …, 2003 - journals.lww.com
The p38 mitogen-activated protein kinase (MAPK) pathway is a pro-inflammatory signal
transduction pathway. The aim of this study was to examine the role of this pathway in acute
renal inflammation. Immunostaining localized components of the p38 MAPK pathway (p38α,
p-p38, p-ATF-2) in normal glomeruli, to podocytes, and occasional endothelial cells. This
study identified an eightfold increase in glomerular activation of p38 MAPK (phosphorylated
p38, p-p38) within 3 h of the induction of rat anti–glomerular basement membrane (GBM) …
transduction pathway. The aim of this study was to examine the role of this pathway in acute
renal inflammation. Immunostaining localized components of the p38 MAPK pathway (p38α,
p-p38, p-ATF-2) in normal glomeruli, to podocytes, and occasional endothelial cells. This
study identified an eightfold increase in glomerular activation of p38 MAPK (phosphorylated
p38, p-p38) within 3 h of the induction of rat anti–glomerular basement membrane (GBM) …