[HTML][HTML] Gas6 induces mesangial cell proliferation via latent transcription factor STAT3
M Yanagita, H Arai, T Nakano, K Ohashi… - Journal of Biological …, 2001 - ASBMB
Mesangial cell proliferation is essential for the pathogenesis and progression of glomerular
disease. Previously, we showed that Gas6 plays a pivotal role in mesangial cell proliferation
in vitro and in vivo. In the present study, we identified downstream targets of Gas6 signaling
to examine the role in mesangial cell proliferation in vitro and in vivo. We found that Gas6
tyrosine phosphorylates STAT3 (signal transducers and activators of transcription) with
concomitant translocation to the nucleus and induces STAT3-dependent transcriptional …
disease. Previously, we showed that Gas6 plays a pivotal role in mesangial cell proliferation
in vitro and in vivo. In the present study, we identified downstream targets of Gas6 signaling
to examine the role in mesangial cell proliferation in vitro and in vivo. We found that Gas6
tyrosine phosphorylates STAT3 (signal transducers and activators of transcription) with
concomitant translocation to the nucleus and induces STAT3-dependent transcriptional …