Adenosine induces vasoconstriction through Gi-dependent activation of phospholipase C in isolated perfused afferent arterioles of mice
PB Hansen, H Castrop, J Briggs… - Journal of the American …, 2003 - journals.lww.com
Adenosine induces vasoconstriction of renal afferent arterioles through activation of A1
adenosine receptors (A1AR). A1AR are directly coupled to Gi/Go, resulting in inhibition of
adenylate cyclase, but the contribution of this signaling pathway to smooth muscle cell
activation is unclear. In perfused afferent arterioles from mouse kidney, adenosine and the
A1 agonist N 6-cyclohexyladenosine, when added to the bath, caused constriction in the
concentration range of 10− 9 to 10− 6 M (mean diameter: control, 8.8±0.3 μm; adenosine at …
adenosine receptors (A1AR). A1AR are directly coupled to Gi/Go, resulting in inhibition of
adenylate cyclase, but the contribution of this signaling pathway to smooth muscle cell
activation is unclear. In perfused afferent arterioles from mouse kidney, adenosine and the
A1 agonist N 6-cyclohexyladenosine, when added to the bath, caused constriction in the
concentration range of 10− 9 to 10− 6 M (mean diameter: control, 8.8±0.3 μm; adenosine at …