DC-SIGN interactions with human immunodeficiency virus: virus binding and transfer are dissociable functions
S Pöhlmann, GJ Leslie, TG Edwards… - Journal of …, 2001 - Am Soc Microbiol
Journal of virology, 2001•Am Soc Microbiol
The C-type lectins DC-SIGN and DC-SIGNR capture and transfer human immunodeficiency
virus (HIV) to susceptible cells, although the underlying mechanism is unclear. Here we
show that DC-SIGN/DC-SIGNR-mediated HIV transmission involves dissociable binding and
transfer steps, indicating that efficient virus transmission is not simply due to tethering of
virus to the cell surface.
virus (HIV) to susceptible cells, although the underlying mechanism is unclear. Here we
show that DC-SIGN/DC-SIGNR-mediated HIV transmission involves dissociable binding and
transfer steps, indicating that efficient virus transmission is not simply due to tethering of
virus to the cell surface.
Abstract
The C-type lectins DC-SIGN and DC-SIGNR capture and transfer human immunodeficiency virus (HIV) to susceptible cells, although the underlying mechanism is unclear. Here we show that DC-SIGN/DC-SIGNR-mediated HIV transmission involves dissociable binding and transfer steps, indicating that efficient virus transmission is not simply due to tethering of virus to the cell surface.
American Society for Microbiology