DC-SIGN interactions with human immunodeficiency virus: virus binding and transfer are dissociable functions

S Pöhlmann, GJ Leslie, TG Edwards… - Journal of …, 2001 - Am Soc Microbiol
S Pöhlmann, GJ Leslie, TG Edwards, T Macfarlan, JD Reeves, K Hiebenthal-Millow…
Journal of virology, 2001Am Soc Microbiol
The C-type lectins DC-SIGN and DC-SIGNR capture and transfer human immunodeficiency
virus (HIV) to susceptible cells, although the underlying mechanism is unclear. Here we
show that DC-SIGN/DC-SIGNR-mediated HIV transmission involves dissociable binding and
transfer steps, indicating that efficient virus transmission is not simply due to tethering of
virus to the cell surface.
Abstract
The C-type lectins DC-SIGN and DC-SIGNR capture and transfer human immunodeficiency virus (HIV) to susceptible cells, although the underlying mechanism is unclear. Here we show that DC-SIGN/DC-SIGNR-mediated HIV transmission involves dissociable binding and transfer steps, indicating that efficient virus transmission is not simply due to tethering of virus to the cell surface.
American Society for Microbiology