Bacterial invasion: the paradigms of enteroinvasive pathogens

P Cossart, PJ Sansonetti - Science, 2004 - science.org
P Cossart, PJ Sansonetti
Science, 2004science.org
Invasive bacteria actively induce their own uptake by phagocytosis in normally
nonphagocytic cells and then either establish a protected niche within which they survive
and replicate, or disseminate from cell to cell by means of an actin-based motility process.
The mechanisms underlying bacterial entry, phagosome maturation, and dissemination
reveal common strategies as well as unique tactics evolved by individual species to
establish infection.
Invasive bacteria actively induce their own uptake by phagocytosis in normally nonphagocytic cells and then either establish a protected niche within which they survive and replicate, or disseminate from cell to cell by means of an actin-based motility process. The mechanisms underlying bacterial entry, phagosome maturation, and dissemination reveal common strategies as well as unique tactics evolved by individual species to establish infection.
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