HIV-1 entry and its inhibition
TC Pierson, RW Doms - Cellular Factors Involved in Early Steps of …, 2003 - Springer
TC Pierson, RW Doms
Cellular Factors Involved in Early Steps of Retroviral Replication, 2003•SpringerEntry of HIV-1 virions into cells is a complex and dynamic process carried out by envelope
(Env) glycoproteins on the surface of the virion that promote the thermodynamically
unfavorable fusion of highly stable viral and target cell membranes. Insight gained from
studies of the mechanism of viral entry allowed insight into the design of novel inhibitors of
HIV-1 entry, several of which are now in clinical trials. This review highlights the mechanism
by which viral and cellular proteins mediate entry of HIV-1 into permissive cells, with an …
(Env) glycoproteins on the surface of the virion that promote the thermodynamically
unfavorable fusion of highly stable viral and target cell membranes. Insight gained from
studies of the mechanism of viral entry allowed insight into the design of novel inhibitors of
HIV-1 entry, several of which are now in clinical trials. This review highlights the mechanism
by which viral and cellular proteins mediate entry of HIV-1 into permissive cells, with an …
Abstract
Entry of HIV-1 virions into cells is a complex and dynamic process carried out by envelope (Env) glycoproteins on the surface of the virion that promote the thermodynamically unfavorable fusion of highly stable viral and target cell membranes. Insight gained from studies of the mechanism of viral entry allowed insight into the design of novel inhibitors of HIV-1 entry, several of which are now in clinical trials. This review highlights the mechanism by which viral and cellular proteins mediate entry of HIV-1 into permissive cells, with an emphasis on targeting this process in the design of novel therapies that target distinct steps of the entry process, including antagonizing receptor binding events and blocking conformational changes intimately involved in membrane fusion.
Springer