[HTML][HTML] Interaction and Functional Cooperation of NF-κB with Smads: transcriptional regulation of the junbpromoter
T López-Rovira, E Chalaux, JL Rosa, R Bartrons… - Journal of Biological …, 2000 - ASBMB
The transforming growth factor− β (TGF− β) family of cytokines regulates diverse cellular
processes through control of the expression of target genes. Smad proteins are a recently
identified family of signal transducers for members of the TGF− β family. Smads act as
transcriptional regulators through binding to DNA and interacting with a variety of
transcription factors. Here, we identified a κB site as a TGF-β-responsive region in the 3′-
downstream junB promoter region. We also demonstrate that κB sites alone are sufficient to …
processes through control of the expression of target genes. Smad proteins are a recently
identified family of signal transducers for members of the TGF− β family. Smads act as
transcriptional regulators through binding to DNA and interacting with a variety of
transcription factors. Here, we identified a κB site as a TGF-β-responsive region in the 3′-
downstream junB promoter region. We also demonstrate that κB sites alone are sufficient to …