[HTML][HTML] The IKK-2/IκBα/NF-κB pathway plays a key role in the regulation of CCR3 and eotaxin-1 in fibroblasts: a critical link to dermatitis in IκBα-deficient mice
MA Huber, A Denk, RU Peter, L Weber, N Kraut… - Journal of Biological …, 2002 - ASBMB
Tumor necrosis factor (TNF)-α-induced phosphorylation of the IκB proteins by the IκB kinase
(IKK) complex containing IKK-2 and subsequent degradation of the IκB proteins are
prerequisites for NF-κB activation, resulting in the stimulation of a variety of pro-inflammatory
target genes. The CC chemokine eotaxin-1 is a potent chemoattractant for eosinophils and
Th2 lymphocytes, may play an important role in the pathogenesis of atopic dermatitis, and
acts via binding to its receptor CCR3. To investigate the role of NF-κB signaling in the …
(IKK) complex containing IKK-2 and subsequent degradation of the IκB proteins are
prerequisites for NF-κB activation, resulting in the stimulation of a variety of pro-inflammatory
target genes. The CC chemokine eotaxin-1 is a potent chemoattractant for eosinophils and
Th2 lymphocytes, may play an important role in the pathogenesis of atopic dermatitis, and
acts via binding to its receptor CCR3. To investigate the role of NF-κB signaling in the …