The role of high-density lipoproteins in oxidation and inflammation
BJ Van Lenten, M Navab, D Shih, AM Fogelman… - Trends in cardiovascular …, 2001 - Elsevier
High-density lipoproteins (HDL) in the basal state are anti-inflammatory, capable of
destroying oxidized lipids that generate an inflammatory response. However, HDL during
acute inflammation are altered and become pro-inflammatory. This “chameleon-like” nature
of HDL is considered to be due to the complex composition of HDL. The data reviewed here
demonstrate the key role of HDL in modulating inflammation and its implications for
atherogenesis.
destroying oxidized lipids that generate an inflammatory response. However, HDL during
acute inflammation are altered and become pro-inflammatory. This “chameleon-like” nature
of HDL is considered to be due to the complex composition of HDL. The data reviewed here
demonstrate the key role of HDL in modulating inflammation and its implications for
atherogenesis.