[HTML][HTML] Oxidation of methionine residues to methionine sulfoxides does not decrease potential antiatherogenic properties of apolipoprotein AI
U Panzenböck, L Kritharides, M Raftery… - Journal of Biological …, 2000 - ASBMB
The initial stage of oxidation of high density lipoproteins (HDL) is accompanied by the lipid
hydroperoxide-dependent, selective oxidation of two of the three Met residues of
apolipoprotein AI (apoA-I) to Met sulfoxides (Met (O)). Formation of such selectively oxidized
apoA-I (ie apoA-I+ 32) may affect the antiatherogenic properties of HDL, because it has
been suggested that Met 86 and Met 112 are important for cholesterol efflux and Met 148 is
involved in the activation of lecithin: cholesterol acyl transferase (LCAT). We therefore …
hydroperoxide-dependent, selective oxidation of two of the three Met residues of
apolipoprotein AI (apoA-I) to Met sulfoxides (Met (O)). Formation of such selectively oxidized
apoA-I (ie apoA-I+ 32) may affect the antiatherogenic properties of HDL, because it has
been suggested that Met 86 and Met 112 are important for cholesterol efflux and Met 148 is
involved in the activation of lecithin: cholesterol acyl transferase (LCAT). We therefore …