Scavenger receptor BI (SR-BI) facilitates the efflux of cellular cholesterol to plasma high
density lipoprotein (HDL). Recently, the ATP-binding cassette transporter 1 (ABC1) was
identified as a key mediator of cholesterol efflux to apolipoproteins and HDL. The goal of the
present study was to determine a possible interaction between the SR-BI and ABC1
cholesterol efflux pathways in macrophages. Free cholesterol efflux to HDL was increased
(∼ 2.2-fold) in SR-BI transfected RAW macrophages in association with increased SR-BI …