[HTML][HTML] Nitric oxide is a physiological substrate for mammalian peroxidases
HM Abu-Soud, SL Hazen - Journal of Biological Chemistry, 2000 - ASBMB
We now show that NO serves as a substrate for multiple members of the mammalian
peroxidase superfamily under physiological conditions. Myeloperoxidase (MPO), eosinophil
peroxidase, and lactoperoxidase all catalytically consumed NO in the presence of the co-
substrate hydrogen peroxide (H 2 O 2). Near identical rates of NO consumption by the
peroxidases were observed in the presenceversus absence of plasma levels of Cl−.
Although rates of NO consumption in buffer were accelerated in the presence of a …
peroxidase superfamily under physiological conditions. Myeloperoxidase (MPO), eosinophil
peroxidase, and lactoperoxidase all catalytically consumed NO in the presence of the co-
substrate hydrogen peroxide (H 2 O 2). Near identical rates of NO consumption by the
peroxidases were observed in the presenceversus absence of plasma levels of Cl−.
Although rates of NO consumption in buffer were accelerated in the presence of a …