Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy
MH Shishehbor, RJ Aviles, ML Brennan, X Fu… - Jama, 2003 - jamanetwork.com
ContextFormation of nitric oxide–derived oxidants may serve as a mechanism linking
inflammation to development of atherosclerosis. Nitrotyrosine, a specific marker for protein
modification by nitric oxide–derived oxidants, is enriched in human atherosclerotic lesions
and low-density lipoprotein (LDL) recovered from human atheroma. ObjectivesTo determine
whether systemic levels of nitrotyrosine are associated with the prevalence of coronary
artery disease (CAD) and are modulated by hydroxymethylglutaryl coenzyme-A reductase …
inflammation to development of atherosclerosis. Nitrotyrosine, a specific marker for protein
modification by nitric oxide–derived oxidants, is enriched in human atherosclerotic lesions
and low-density lipoprotein (LDL) recovered from human atheroma. ObjectivesTo determine
whether systemic levels of nitrotyrosine are associated with the prevalence of coronary
artery disease (CAD) and are modulated by hydroxymethylglutaryl coenzyme-A reductase …