Complete mapping of crystallization pathways during cholesterol precipitation from model bile: influence of physical-chemical variables of pathophysiologic relevance …
DQ Wang, MC Carey - Journal of lipid research, 1996 - ASBMB
Using complementary physical-chemical techniques we defined five different crystallization
pathways as functions of time (30 days) and increasing lecithin (egg yolk) content in
pathophysiologically relevant model biles super-saturated (cholesterol saturation indices,
1.2-2.7) by dilution of approximately equal to 29 g/dl bile salt-lecithin-cholesterol micellar
solutions. As evidenced by quasi-elastic light-scattering spectroscopy, supersaturation was
heralded by the appearance of unilamellar vesicles. With the lowest lecithin contents, arc …
pathways as functions of time (30 days) and increasing lecithin (egg yolk) content in
pathophysiologically relevant model biles super-saturated (cholesterol saturation indices,
1.2-2.7) by dilution of approximately equal to 29 g/dl bile salt-lecithin-cholesterol micellar
solutions. As evidenced by quasi-elastic light-scattering spectroscopy, supersaturation was
heralded by the appearance of unilamellar vesicles. With the lowest lecithin contents, arc …