Correlating structure and function in ATP-sensitive K+ channels
FM Ashcroft, FM Gribble - Trends in neurosciences, 1998 - cell.com
FM Ashcroft, FM Gribble
Trends in neurosciences, 1998•cell.comATP-sensitive K+ channels couple cell metabolism to electrical activity in nerve, muscle and
endocrine cells, and play important roles in these tissues under both physiological and
pathological conditions. The K ATP channel is an octameric complex of two unrelated types
of subunit: a pore-forming subunit (Kir6. 2) and a regulatory subunit, the sulphonylurea
receptor (SUR). This review focuses on the regulation of K ATP channel activity by
nucleotides and cell metabolism and considers which regulatory mechanisms are intrinsic to …
endocrine cells, and play important roles in these tissues under both physiological and
pathological conditions. The K ATP channel is an octameric complex of two unrelated types
of subunit: a pore-forming subunit (Kir6. 2) and a regulatory subunit, the sulphonylurea
receptor (SUR). This review focuses on the regulation of K ATP channel activity by
nucleotides and cell metabolism and considers which regulatory mechanisms are intrinsic to …
Abstract
ATP-sensitive K+ channels couple cell metabolism to electrical activity in nerve, muscle and endocrine cells, and play important roles in these tissues under both physiological and pathological conditions. The KATP channel is an octameric complex of two unrelated types of subunit: a pore-forming subunit (Kir6.2) and a regulatory subunit, the sulphonylurea receptor (SUR). This review focuses on the regulation of KATP channel activity by nucleotides and cell metabolism and considers which regulatory mechanisms are intrinsic to Kir6.2 and which are conferred by association with SUR.
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