Effects of acadesine on myocardial infarction, stroke, and death following surgery: a meta-analysis of the 5 international randomized trials
DT Mangano - Jama, 1997 - jamanetwork.com
Objective.—To determine the effects of a purine nucleoside, acadesine, on the incidence of
fatal and nonfatal cardiovascular and cerebrovascular complications following coronary
artery bypass graft (CABG) surgery. Data Sources.—Individual patient data from 5
randomized, placebo-controlled, double-blind clinical trials, including 81 international
medical centers of the United States, Canada, and Europe. Study Selection.—All patients
from all clinical trials were included: a total of 4043 patients undergoing CABG surgery …
fatal and nonfatal cardiovascular and cerebrovascular complications following coronary
artery bypass graft (CABG) surgery. Data Sources.—Individual patient data from 5
randomized, placebo-controlled, double-blind clinical trials, including 81 international
medical centers of the United States, Canada, and Europe. Study Selection.—All patients
from all clinical trials were included: a total of 4043 patients undergoing CABG surgery …