[HTML][HTML] High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP …
N Kudo, AJ Barr, RL Barr, S Desai… - Journal of Biological …, 1995 - ASBMB
We determined whether high fatty acid oxidation rates during aerobic reperfusion of
ischemic hearts could be explained by a decrease in malonyl-CoA levels, which would
relieve inhibition of carnitine palmitoyltransferase 1, the rate-limiting enzyme involved in
mitochondrial uptake of fatty acids. Isolated working rat hearts perfused with 1.2 mM
palmitate were subjected to 30 min of global ischemia, followed by 60 min of aerobic
reperfusion. Fatty acid oxidation rates during reperfusion were 136% higher than rates seen …
ischemic hearts could be explained by a decrease in malonyl-CoA levels, which would
relieve inhibition of carnitine palmitoyltransferase 1, the rate-limiting enzyme involved in
mitochondrial uptake of fatty acids. Isolated working rat hearts perfused with 1.2 mM
palmitate were subjected to 30 min of global ischemia, followed by 60 min of aerobic
reperfusion. Fatty acid oxidation rates during reperfusion were 136% higher than rates seen …