[HTML][HTML] Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase
S Kanda, Y Mochizuki, T Suematsu, Y Miyata… - Journal of Biological …, 2003 - ASBMB
Sonic hedgehog (Shh) acts as a morphogen in many cell types. Recent studies have shown
that hedgehog signaling is involved in vascular development as well as postnatal
angiogenesis. However, the direct action of Shh on cultured endothelial cells has not been
clearly shown. To address this issue, we examined the effect of Shh on morphological
changes by murine brain capillary endothelial cells (IBE cells) and human umbilical
endothelial cells (HUVECs). Shh induced capillary morphogenesis by these cells. The effect …
that hedgehog signaling is involved in vascular development as well as postnatal
angiogenesis. However, the direct action of Shh on cultured endothelial cells has not been
clearly shown. To address this issue, we examined the effect of Shh on morphological
changes by murine brain capillary endothelial cells (IBE cells) and human umbilical
endothelial cells (HUVECs). Shh induced capillary morphogenesis by these cells. The effect …