Two patients with orbital hypotelorism, flat nose, and bilateral lateral cleft of lip and palate
with a hypoplastic philtrumpremaxilla Anlage are described. Both patients had
holoprosencephaly (arhinencephaly), a brain defect characterized by an arrest in
prosencephalic cleavage with no or incomplete proplasia of frontal poles and olfactory
bulbs. The two patients are an intermediate stage in a graded series of median facio-
cerebral malformations which begins with cyclopia, and then, as face and brain transform …