Teratogenesis of holoprosencephaly
MM Cohen Jr, K Shiota - American journal of medical genetics, 2002 - Wiley Online Library
MM Cohen Jr, K Shiota
American journal of medical genetics, 2002•Wiley Online LibraryTeratogenic causes of holoprosencephaly are critically assessed. A brief general review of
holoprosencephaly is followed by four tables summarizing etiologic factors. Subjects
evaluated here include: 1) maternal diabetes; 2) ethyl alcohol; 3) retinoic acid; 4) mutated
genes and teratogens involving the sonic hedgehog signaling network and cholesterol
biosynthesis; and 5) cholesterol trafficking, sterol adducts, target tissue response, and sterol
sensing domain.© 2002 Wiley‐Liss, Inc.
holoprosencephaly is followed by four tables summarizing etiologic factors. Subjects
evaluated here include: 1) maternal diabetes; 2) ethyl alcohol; 3) retinoic acid; 4) mutated
genes and teratogens involving the sonic hedgehog signaling network and cholesterol
biosynthesis; and 5) cholesterol trafficking, sterol adducts, target tissue response, and sterol
sensing domain.© 2002 Wiley‐Liss, Inc.
Abstract
Teratogenic causes of holoprosencephaly are critically assessed. A brief general review of holoprosencephaly is followed by four tables summarizing etiologic factors. Subjects evaluated here include: 1) maternal diabetes; 2) ethyl alcohol; 3) retinoic acid; 4) mutated genes and teratogens involving the sonic hedgehog signaling network and cholesterol biosynthesis; and 5) cholesterol trafficking, sterol adducts, target tissue response, and sterol sensing domain. © 2002 Wiley‐Liss, Inc.
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