[HTML][HTML] Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12
Since the bone morphogenetic proteins (BMPs) are members of the transforming growth
factor-β (TGF-β) superfamily that induce the differentiation of mesenchymal precursor cells
into the osteogenic cells, we identified the relevant signaling molecules responsible for
mediating BMP-2 effects on mesenchymal precursor cells. BMP-2 induces osteoblastic
differentiation of the pluripotent mesenchymal cell line C2C12 by increasing alkaline
phosphatase activity and osteocalcin production. As recent studies have demonstrated that …
factor-β (TGF-β) superfamily that induce the differentiation of mesenchymal precursor cells
into the osteogenic cells, we identified the relevant signaling molecules responsible for
mediating BMP-2 effects on mesenchymal precursor cells. BMP-2 induces osteoblastic
differentiation of the pluripotent mesenchymal cell line C2C12 by increasing alkaline
phosphatase activity and osteocalcin production. As recent studies have demonstrated that …