[HTML][HTML] The JNKK2-JNK1 fusion protein acts as a constitutively active c-Jun kinase that stimulates c-Jun transcription activity
C Zheng, J Xiang, T Hunter, A Lin - Journal of Biological Chemistry, 1999 - ASBMB
c-Jun N-terminal protein kinase (JNK), a member of the mitogen-activated protein (MAP)
kinase family, regulates gene expression in response to various extracellular stimuli. JNK is
activated by JNK-activating kinase (JNKK1 and JNKK2), a subfamily of the dual specificity
MAP kinase kinase (MEK) family, through phosphorylation on threonine (Thr) 183 and
tyrosine (Tyr) 185 residues. The physiological functions of the JNK pathway, however, are
not completely understood. A major obstacle is the lack of specific and activated kinase …
kinase family, regulates gene expression in response to various extracellular stimuli. JNK is
activated by JNK-activating kinase (JNKK1 and JNKK2), a subfamily of the dual specificity
MAP kinase kinase (MEK) family, through phosphorylation on threonine (Thr) 183 and
tyrosine (Tyr) 185 residues. The physiological functions of the JNK pathway, however, are
not completely understood. A major obstacle is the lack of specific and activated kinase …