Induction of broad and potent anti-human immunodeficiency virus immune responses in rhesus macaques by priming with a DNA vaccine and boosting with protein …
G Otten, M Schaefer, C Greer… - Journal of …, 2003 - Am Soc Microbiol
G Otten, M Schaefer, C Greer, M Calderon-Cacia, D Coit, J Kazzaz, A Medina-Selby…
Journal of virology, 2003•Am Soc MicrobiolSeveral vaccine technologies were evaluated for their abilities to induce anti-human
immunodeficiency virus Gag immune responses in rhesus macaques. While no vaccine
alone was able to induce broad and strong immune responses, these were achieved by
priming with Gag DNA and boosting with Gag protein adsorbed to polylactide coglycolide
microparticles. This regimen elicited strong antibodies, helper T cells, and cytotoxic T
lymphocytes and thus holds promise as an effective vaccination scheme.
immunodeficiency virus Gag immune responses in rhesus macaques. While no vaccine
alone was able to induce broad and strong immune responses, these were achieved by
priming with Gag DNA and boosting with Gag protein adsorbed to polylactide coglycolide
microparticles. This regimen elicited strong antibodies, helper T cells, and cytotoxic T
lymphocytes and thus holds promise as an effective vaccination scheme.
Abstract
Several vaccine technologies were evaluated for their abilities to induce anti-human immunodeficiency virus Gag immune responses in rhesus macaques. While no vaccine alone was able to induce broad and strong immune responses, these were achieved by priming with Gag DNA and boosting with Gag protein adsorbed to polylactide coglycolide microparticles. This regimen elicited strong antibodies, helper T cells, and cytotoxic T lymphocytes and thus holds promise as an effective vaccination scheme.
American Society for Microbiology