Hyperimmunization of apo-E-deficient mice with homologous malondialdehyde low-density lipoprotein suppresses early atherogenesis
J George, A Afek, B Gilburd, H Levkovitz, A Shaish… - Atherosclerosis, 1998 - Elsevier
The role of the immune system in modulating atherosclerosis has recently been the subject
of intensive research. Several previous authors have put forward a paradigm of the
autoimmune process occurring in the vicinity of the plaque. Two recent studies have shown
that immunization of rabbits with homologous modified low-density lipoprotein (LDL) led to
suppression of atherosclerosis. In the current study we evaluated the effects of homologous
malondialdehyde (MDA)-LDL immunizations on atherogenesis in apo-E-deficient mice. Two …
of intensive research. Several previous authors have put forward a paradigm of the
autoimmune process occurring in the vicinity of the plaque. Two recent studies have shown
that immunization of rabbits with homologous modified low-density lipoprotein (LDL) led to
suppression of atherosclerosis. In the current study we evaluated the effects of homologous
malondialdehyde (MDA)-LDL immunizations on atherogenesis in apo-E-deficient mice. Two …