[HTML][HTML] Interferon-γ impairs physiologic downregulation of cyclin-dependent kinase inhibitor, p27Kip1, during G1 phase progression in macrophages
M Matsuoka, I Nishimoto, S Asano - Experimental hematology, 1999 - Elsevier
Cell cycle progression of mouse macrophage cells was impaired by interferon-gamma (IFN-
γ). The blockage of G1/S transition was associated with diminution of cyclin-dependent
kinase-2 (CDK2)-associated kinase activities. The expression of p21Cip1 was not
upregulated by IFN-γ. Instead, the physiologic downregulation of p27Kip1 necessary for
normal cell cycle progression did not take place sufficiently in the presence of IFN-γ. During
normal cell cycle progression, the levels of p27Kip1 were maximal at early G1 and then …
γ). The blockage of G1/S transition was associated with diminution of cyclin-dependent
kinase-2 (CDK2)-associated kinase activities. The expression of p21Cip1 was not
upregulated by IFN-γ. Instead, the physiologic downregulation of p27Kip1 necessary for
normal cell cycle progression did not take place sufficiently in the presence of IFN-γ. During
normal cell cycle progression, the levels of p27Kip1 were maximal at early G1 and then …