Human C′ 3: evidence for the liver as the primary site of synthesis
CA Alper, AM Johnson, AG Birtch, FD Moore - Science, 1969 - science.org
CA Alper, AM Johnson, AG Birtch, FD Moore
Science, 1969•science.orglymphocytes and thymocytes, EL4 as- Liver as the Primary Site types, F1, FO., FO.5 So.6, and
S1, are Page 1 80 .9 60 0n i^ 40 a 20 Strain A lymphocytes (%) 80 60 40 20 * H*2a Anti H2b *
serum - 0 0 0 0 o 0 0 0 H-2 bAnti H-2a 0 serum 0 . Ot _, II 0 20 40 60 80 100 C57BL/6
lymphocytes l%l Fig. Cytotoxic tests with H-2 antiserums on C57BL/6 mouse lymphocytes and
on A-strain mouse lymphocyte suspensions, mixed in various proportions by volume. The slight
curvature of the two plots and their intersection near 60 percent (abscissa) rather thanat 50 …
S1, are Page 1 80 .9 60 0n i^ 40 a 20 Strain A lymphocytes (%) 80 60 40 20 * H*2a Anti H2b *
serum - 0 0 0 0 o 0 0 0 H-2 bAnti H-2a 0 serum 0 . Ot _, II 0 20 40 60 80 100 C57BL/6
lymphocytes l%l Fig. Cytotoxic tests with H-2 antiserums on C57BL/6 mouse lymphocytes and
on A-strain mouse lymphocyte suspensions, mixed in various proportions by volume. The slight
curvature of the two plots and their intersection near 60 percent (abscissa) rather thanat 50 …
The liver is the primary, if not sole, site of synthesis of the third component of human complement, as shown by a change in the recipient from C′3 FS0.6 to C′3 SS, the donor type, following homotransplantation of the liver.
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