Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40
LSK Walker, A Gulbranson-Judge, S Flynn, T Brocker… - Immunology today, 2000 - cell.com
LSK Walker, A Gulbranson-Judge, S Flynn, T Brocker, PJL Lane
Immunology today, 2000•cell.comGiven the importance of responding to infections with the right defensive strategy, much
interest has focused on cytokine differentiation in CD4+ T cells. However, relatively little is
known of the logistics of T-cell help for B cells. Here, Lucy Walker and colleagues propose
key roles for CD28 and OX40 in coordinating the selection, expansion and migration of
CD4+ T cells to B-cell follicles.
interest has focused on cytokine differentiation in CD4+ T cells. However, relatively little is
known of the logistics of T-cell help for B cells. Here, Lucy Walker and colleagues propose
key roles for CD28 and OX40 in coordinating the selection, expansion and migration of
CD4+ T cells to B-cell follicles.
Abstract
Given the importance of responding to infections with the right defensive strategy, much interest has focused on cytokine differentiation in CD4+ T cells. However, relatively little is known of the logistics of T-cell help for B cells. Here, Lucy Walker and colleagues propose key roles for CD28 and OX40 in coordinating the selection, expansion and migration of CD4+ T cells to B-cell follicles.
cell.com